Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Gossamer Bio Inc. has released new data showing its inhaled kinase inhibitor, seralutinib, has long-lasting effects on ...

Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical characteristics of choroidal metastasis in this patient population and report treatment ...

Tagrisso was linked to higher cardiac risks in patients with EGFR-mutant NSCLC, including a four-fold rise in cardiac events ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1 ... decreases sorafenib concentrations. Similar effects are observed with dexamethasone and St John's wort.

It was found that a phospho-dead mutation at Y163 abolished the inhibitory effects of ING5 overexpression ... a potential candidate. TIE1, a receptor tyrosine kinase, was found to be upregulated ...

I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...