called retinoic acid. More than 40% of individuals will develop osteoarthritis (OA) during their lifetime. Hand (OA) is an extremely common form of OA and there are currently no disease modifying ...

New research has proposed mechanoinflammation as the primary driver of hand osteoarthritis and identified the importance of retinoic acid in its development. The research team showed the drug ...

Scientists investigating new treatments for hand osteoarthritis (OA ... The molecule is called retinoic acid, and it is synthesized via the ALDH1A2 gene. Through RNA sequencing, the scientists ...

Cells from these were analyzed alongside experimental models, and it was found that people at risk of hand OA had low levels of retinoic acid. “ALDH1A2 is the key synthetic enzyme for the ...

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid. Nature Communications , 2025; 16 (1) DOI: 10.1038/s41467-025-57185-y Cite This Page : ...

Topical retinoids (for example, tretinoin) and retinoid analogues (for example, adapalene and tazarotene) help normalize hyperkeratinization and have demonstrated significant anti-inflammatory ...

But before we dig deeper into your different retinoid options, here’s one more canine comparison: All puppies become dogs when they grow up, and all retinoids become retinoic acid.

To date scientists have known that retinoic acid in the gut-draining lymph nodes promotes effector CD8 T cell migration to the intestines, enhancing the immune response.

When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10-15%. However, this effect was only evident in post ...