A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription.

The SAM-I, SAM-II, and SAM-III riboswitch classes are members of the SAM riboswitch family. The aptamer domain from each class has unique secondary (top row) and tertiary (bottom row) structural ...

The role of RNA in information transfer and catalysis highlights its dual functionalities. Our laboratory has a long-standing interest in RNA folding, recognition, and catalysis. We are especially ...