If tumor suppressor genes get turned off due to mutations, cells are at risk of becoming cancerous and growing uncontrollably. Most cancer cells have more than 60 mutations. A challenge for ...

The retinoblastoma tumor-suppressor gene (Rb1) has been a focal point for ... the substrate-recognition subunit of the ubiquitin protein ligase SCF SKP2. Binding of pRb to Skp2 prevents ...

Tumor suppressor genes have an important role in the prevention of cancer. Functioning tumor suppressor genes encode proteins which inhibit tumor growth through different mechanisms. Damage to ...

The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved ...

Scientists have developed a method which is able to switch ‘tumor suppressor’ genes back on after they have been silenced by cancer cells. The discovery has strong implications for the ...

The research confirms previous knowledge that a decreased copy number correlates with mutations in tumor suppressor genes (which hinders their cancer-protective functions), while an increased copy ...

They confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipitates events culminating in an aggressive type of ...

Scientists have found a tumor suppressor gene, RASA2, that drives a particularly deadly form of melanoma as well as regulates a key protein, RAS, that is a major oncogene. The discovery is "highly ...

LMU researchers have identified the 14-3-3sigma gene as an important suppressor of carcinogenesis ... of gene expression in several thousands of tumor samples isolated from patients with ...

When it comes to genes associated with cancer, none have been studied more extensively than p53, a tumor suppressor gene that serves as the guardian of our genetic information.