Selectins mediate leukocyte tethering and rolling ... these extracellular stimuli activate integrins, which mediate adhesion of leukocytes. The selectin family of cell adhesion molecules includes ...

Homing begins in the hydrodynamic environment of the circulation, where T cells use selectins to roll and integrins to arrest on the cuboidal endothelial cells that line the high endothelial ...

With the discovery of chemokines, chemokine receptors, integrins and selectins, the concept of leukocyte recruitment started to emerge. Initially, the process was thought to entail three steps ...

On the other hand, integrins bind to different types of adhesion molecules to promote cell to extracellular matrix binding. Although not mentioned in this study, selectins are adhesion molecules ...