These side products are formed during sphingolipid synthesis, when the key regulatory enzyme serine palmitoyltransferase (SPT) metabolizes alanine instead of its preferred substrate, serine 8.

30 A defect in carnosinase activity, preventing degradation of dipeptide, might elevate free β-alanine levels; one would also expect an elevation of free carnosine levels, particularly in urine.

They changed the reactive serine (serine 221) in subtilisin to alanine. This mutated enzyme still bound substrates, but they found its ability to act as a catalyst was reduced by a factor of a ...

However, beta-alanine joins with the amino acid histidine to form a dipeptide called carnosine. The body stores carnosine in the muscles and other tissues. Carnosine helps reduce acid accumulation ...

Where there is supposed to be alanine, there is a serine or glycine instead." In 2006, the Schimmel-Yang lab contributed to research led by the Ackerman group at Jackson Laboratories that showed ...

They figured out the chemical basis for why glycine and serine are often confused for alanine, which led them to conclude that the second check has been put in place to make sure alanine and not ...