These findings indicate that the expression of EMT markers in these cell lines is not dependent on TGF-β signaling pathway, but on the presence of Smad3. We performed miRNA-specific quantitative ...

We measured Smad3 messenger RNA (mRNA) and protein in leukemia cells obtained at diagnosis from 19 children with acute leukemia, including 10 with T-cell acute lymphoblastic leukemia (ALL), 7 with ...

This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. HO-1 induction and inhibition were established in C57BL/6J mice ...

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...

The macrophage-to-myofibroblast transition was also apparent in mouse transplant models and was mediated through what's known as the TGF-/Smad3 signaling pathway. "These findings suggest that ...

Recent studies have shown that CRP exacerbates kidney inflammation and fibrosis through the TGF-β/Smad3 signalling pathway, worsening DKD. The activation of the NLRP3 inflammasome is a key factor ...

"In conclusion, the results indicate that GDF15 activates AMPK protein and inhibits hepatic gluconeogenesis and fibrosis through the reduction of the TGF-β1/SMAD3 pathway", says Vázquez-Carrera.

Using cellular and zebrafish models, the researchers validated their finding that increased levels of VEGFA lead to lower levels of SMAD3 in the brain. Advt The team used stem cells from blood and ...