Small interfering RNAs (siRNAs ... complex can then inhibit transcription of an mRNA molecule that has a sequence complementary to its RNA component. Inside the eukaryotic nucleus, the nucleolus ...

With its discovery of small molecules that activate RNA methylation ... Chemestmed has created a pipeline led by the first-in-class molecule CHMA1004. This lead candidate is in investigational ...

Building on successes in epitranscriptomics, Aqemia aims to develop novel small-molecule drugs against this emerging and promising class of therapeutic targets. In parallel with advancing RNA ...

Finally, Genentech’s alliance with Skyhawk covers the development and commercialisation of small-molecule drugs that modulate RNA splicing, with a particular focus on cancer and ...