MEK Inhibitor-Based Treatments and FDA Approval of Selumetinib (Koselugo) Several clinical trials have investigated the effectiveness of drugs called MEK inhibitors as potential treatments for ...

Chemotherapeutic agents are often used to treat cancer. They combat tumor growth, but also have a number of undesirable side ...

BAY43-9006 (Sorafenib) Small-molecule inhibitor BRAF ... VEGF-2 Phase I AZD6244 Small-molecule inhibitor MEK Phase II PD-325901 Small-molecule inhibitor MEK Phase I SU5416 Small-molecule inhibitor ...

A smaller Phase II study assessed the activity of everolimus in mRCC patients who had failed no more than two prior therapies, one of which was a TKI inhibitor (sorafenib or sunitinib).

For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase (MAPK) mutations (RASopathy), trametinib reduces mortality and morbidity.