For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the traditional two-stage ...

By further analyses of paired samples and microbial relationships, we demonstrate that mucosal microbial communities show distinct alterations across stages of colorectal carcinogenesis.

with TP53 mutations driving the later stages of carcinogenesis. In colitis-associated cancer, a dysplastic precursor lesion arises in the colitic mucosa and progresses through various grades of ...

structure of cells – changes that are associated with the earliest stages of carcinogenesis and cancer progression. The study uses a concept called field carcinogenesis as the source of this new ...

Today, the most effective therapy for cHCC-CCA is surgical removal of the tumors, however, it is only successful if the cancer is detected at a very early stage. “Blocking of IL-6 or agents that ...