With recent advances in sequencing, genotyping arrays, and imputation, GWAS now aim to identify associations with rare and uncommon genetic variants. Here, we describe and evaluate a class of ...

My final thoughts on those Iran vote analyses: From Florida in 2000 and Ohio in 2004 to Mexico City in 2006 to Iran in 2009, tightly contested elections are often accompanied by claims of fraud or ...

Statistical significance is a critical concept in data analysis and research. In essence, it’s a measure that allows researchers to assess whether the results of an experiment or study are due to ...

Post-hoc testing is carried out after a statistical analysis where you have performed multiple significance tests, ‘post-hoc’ coming from the Latin “after this”. Post-hoc analysis represents a way to ...

Significance testing, with appropriate multiple testing correction, is currently the most convenient method for summarizing the evidence for association between a disease and a genetic variant.

The present comment reviews practices revolving around tests of statistical significance. First, the logic of statistical significance testing is presented in an accessible manner; many people who use ...

Investopedia contributors come from a range of backgrounds, and over 25 years there have been thousands of expert writers and editors who have contributed. David Kindness is a Certified Public ...