Despite failing to achieve MRD-negativity after induction, patients with Ph+ acute lymphoblastic leukemia treated with ...

Additionally, the prevalence of steatosis and fibrosis was highest among adults with type 2 diabetes and obesity in both age groups. Hepatic steatosis was common among adults both with and without ...

Background: Biopsy is the usual gold standard for liver steatosis assessment. The aim of this study was to identify a panel of biomarkers (SteatoTest), with sufficient predictive values ...

Ibrahim Aldoss, MD, associate professor, City of Hope, explores recent findings on ponatinib as a first-line treatment for Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL).

Of adults with type 1 diabetes, 100% with obesity and 64.9% with overweight had a positive hepatic steatosis index score. Liver disease screening should be integrated into routine diabetes care.

Steatosis is an accumulation of fat in tissues. It most commonly affects the liver, a condition known as hepatic steatosis. A healthy liver contains some fat, but if fat accounts for more than 5 ...

Ponatinib plus chemotherapy received accelerated FDA approval for newly-diagnosed Ph+ ALL, showing significant efficacy in the PhALLCON trial with 30% achieving MRD-negative CR. Treatment ...

Novel combination of decitabine, venetoclax, and ponatinib achieved bone marrow remission in 80% of patients with untreated chronic myeloid leukemia (CML) and Philadelphia chromosome-positive ...

These conditions are closely tied to hepatic steatosis, a condition characterized by the abnormal accumulation of fat in the liver. Recent genome-wide association studies have identified the 17 ...

Hepatocellular death occurs little under normal conditions in the healthy liver, and it plays a key role as a trigger of liver regeneration; meanwhile, hepatic steatosis increases hepatocellular death ...

Findings showed 30% of patients in the ponatinib arm achieved MRD-negative complete response rate at the end of the induction phase vs 12% of those in the imatinib arm. The Food and Drug ...