Phenotypic features of hepatic stellate cell activation during liver injury and resolution. Following liver injury, hepatic stellate cells undergo "activation" which connotes a transition from ...

In these mice, the researchers found that the liver became smaller, disorganized, and had trouble healing injuries, detoxifying drugs, and regulating the liver's metabolism. Eliminating a single ...

However, chronic liver injury can severely impair this regenerative capacity, leading to liver fibrosis. Hepatic stellate cells (HSCs), the liver's primary mesenchymal cells, play a critical role ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers from the German Cancer Research ...

the researchers genetically engineered mice to eliminate most stellate cells. In these mice, the researchers found that the liver became smaller, disorganized, and had trouble healing injuries, ...

Fibrosis occurs earliest in regions where injury is most severe. In normal liver, hepatic stellate cells (HSCs) are nonparenchymal, quiescent cells whose main functions is to store vitamin A and ...