Study: SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS ... then utilized a cell model that overexpresses FUS with the P525L mutation, which impairs the nuclear localization ...

From liquid droplets to insoluble aggregates FUS normally resides in the nucleus of the cell, but relocates to stress granules in the cytoplasm upon cellular stress. Stress granules are basically ...

Ke Zhang at Johns Hopkins University, Baltimore, thinks the inhibitors may prevent formation of stress granules. These structures are believed to induce TDP-43 and FUS to undergo liquid-liquid phase ...

The results add DPRs to a growing list of ALS/FTD-related proteins that display a knack for phase separation, further supporting the idea that the road to neurodegeneration runs through liquid-phase ...

Scientists are still trying to figure out the exact reason behind it, but recent research has highlighted one possible factor stress granules (SGs). These are tiny clumps of proteins and RNA that ...