By identifying the critical role the urea cycle plays in its development, his findings could pave the way for new medications to treat this currently incurable disease. In a study recently ...

Most interestingly, in the structure the CT domain interacts with the BCCP domain, with biotin and a urea molecule bound at its active site. This structural information and our follow-up biochemical ...

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease. Cell Metabolism , 2022; DOI: 10.1016/j.cmet.2022.05.011 Cite This Page : ...

Included in this report is a study of the excretion of GSA in patients with inborn errors of the urea cycle and the effect of the intraperitoneal injections of urea, arginine and creatinine on its ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)-- Hyperion Therapeutics, Inc. announced today that its investigational compound glycerol phenylbutyrate (HPN-100) has been granted Fast Track ...

Urea cycle disorders are inherited, inborn errors of metabolism present in an estimated 1 in 10,000 births in the United States. Patients with urea cycle disorders are deficient in one of the key ...