This research developed synthetic genes that use Boolean logic gates to achieve specific patterns of gene expression within a plant. The researchers used these gene circuits to redesign the root ...

Synthetic gene circuits are designed to implement novel biologic function, including cellular logic, dynamics and complex cellular and multicellular behaviours. A decade after emerging as a ...

An integrative circuit–host modelling framework for predicting synthetic gene network behaviours. Nature Microbiology , 2017; DOI: 10.1038/s41564-017-0022-5 Cite This Page : ...

“Our synthetic genetic circuits are going to allow us to build very specific ... Brophy designed more than 1,000 potential circuits to be able to manipulate gene expression in plants. She tested them ...

Although synthetic gene circuits have been implemented in various microbes and eukaryotic cell lines, the technology has been difficult to implement in complex organisms like plants because of the ...

This gene "dosing effect" is achieved by installing a negative feedback loop in the synthetic gene circuit, a concept similar to signal distortion control in electronics, a team led by scientists ...

An additional synthetic circuit provides a feedback loop that enables the self-amplification of the repressor so that adding tetracycline further boosts the signal. The Rice team did extensive ...

Del Vecchio’s team designed a synthetic gene circuit to ectopically overexpress a fluorescently-tagged version of the OCT4 transcription factor, while simultaneously blocking the expression of the ...

The installation of synthetic gene circuits that work only in cancer cells represents a new form of cancer immunotherapy, which has shown considerable potential, but still faces stubborn challenges.

Here, two research groups present strategies to allow better control over the timing of immunotherapy using synthetic gene cir­cuits ... targeted IL-2 delivery circuits offer a potential way ...