Lethal genes can also be dominant, conditional, semilethal, or synthetic, depending on the gene or genes involved. The following sections explore these variations in detail. Favism is a sex-linked ...

Tumor development is an evolutionary process driven by an accumulation of mutations allowing cells to acquire traits that can ultimately lead to a cancerous state. [1] As a consequence cancer is ...

Researchers from Tango Therapeutics Inc. have unveiled DNA ligase 1 (LIG1) as a potential new therapeutic target for synthetic lethality in BRCA1-mutant cancers after CRISPR/Cas9 screening.

RNAi as a tool for functional genomics & identification of synthetic lethal interactions RNAi is the mechanism whereby introduction of dsRNA into a cell results in the degradation of a mRNA ...