The Tgfbr1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β ... in a signaling pathway involved in various aspects of embryonic development.

With the newly completed OT-101 and IL-2 Phase 1 trial, Oncotelic is poised to begin further combination trials to determine the added efficacy of OT-101, IL-2, and CKIs in solid tumors such as lung ...

TGF-Beta is a pleiotropic cytokine expressed by almost every tissue and cell type, is stored in abundance in the extracellular matrix, and possesses suppressive and stimulatory signaling pathways.

Studies suggest that by acting as a decoy receptor for myostatin—a protein believed to inhibit muscular tissue ...