“The telomerase RNA (TER) component is essential for telomerase ... of six nucleotides—the building blocks of DNA—with the sequence “GGTTAG” onto the chromosome ends from a template ...

Figure 5: Lsm binding to TER1 promotes telomerase assembly and protects TER1 from degradation. Analysis of the 3′-end sequence distribution for ter1–SmU1 from total RNA revealed that most of ...

"About 70 percent of the human genome is used to make noncoding RNAs that don't code for protein sequences but have other uses." Telomerase RNA is one of the noncoding RNAs that assembles along ...

Telomerase provides an important mechanism for replenishing these lost sequences by reverse transcribing part of its RNA subunit to add telomeric repeats back onto chromosome ends. The realization ...

Scientists have discovered an important step in the maturation pathway of telomerase, the enzyme that replenishes the sequences that ... Telomerase uses part of an RNA subunit as a template ...

One of the mysteries has been how the copied sequence is so precisely defined, since it is a relatively small segment of the much larger telomerase RNA. Stone's group solved the structure of a ...

Telomerase Structure Researchers at John Hopkins University recently elucidated the structure of telomerase by comparing the telomerase RNA genes of 32 different vertebrate species (J.L. Chen et al., ...

Telomerase catalytically adds TTAGGG hexameric nucleotide repeats to the 3′-hydroxyl end of the telomeric leading strand, using a specific sequence in the RNA component as the template.

Geron’s Imetelstat, a lipid-conjugated 13-mer oligonucleotide sequence complementary to the RNA template of the telomerase, directly inhibits the enzyme’s activity. Geron has partnered with ...

This enables subsequent reverse transcription of the same small RNA sequence. "Our model is consistent with the findings of other studies of telomerase and directly reveals the functional ...

die Telomerase-RNA codieren, verursachen die autosomal ... exons where a mutation was predicted to alter splicing; primer sequences are available on request. PCR products were cloned, and the ...

Telomerase is an unusual enzyme in that it is composed of a protein component and an RNA component. The protein is a type of enzyme called a reverse transcriptase, which makes DNA copies of RNA ...