and chromosomal translocations. To avoid the attrition of telomeres, germ-line cells and some somatic cells produce telomerase, an enzyme that catalyzes DNA synthesis to maintain telomere length.

Researchers at the University of California Berkeley have captured the most detailed images to date of telomerase, the enzyme that lengthens the ends of chromosomes and plays a critical role in aging.

The enzyme telomerase can slow aging within cells by lengthening telomeres, a sort of cap at the end of chromosomes that protects DNA and the chromosomes' stability. For the first time ...

“This is the first time that we have identified the detailed structure of the telomerase component from plants,” said co-author Dr. Julian Chen, a professor of biochemistry at Arizona State ...

Cancer researchers are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth. Cancer researchers at UT Southwestern Medical Center are ...

After being injected with the telomerase gene, adult and old mice lived 24 percent and 13 percent longer, respectively. (Source: www.irbbarcelona.org) Scientists are doing their best to give us the ...

Research has recently uncovered a crucial step in the telomerase enzyme catalytic cycle. This catalytic cycle determines the ability of the human telomerase enzyme to synthesize DNA. Research from ...

Now researchers have the best picture yet of this enzyme, called telomerase. Using cryo-electron microscopy, structural biologist Kelly Nguyen and her colleagues describe the structure of ...

Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary ...

Using yeast, the researchers reveal protein interactions that could explain how the enzyme telomerase is tightly regulated to prevent cells from dividing uncontrollably or aging prematurely.