Antithrombin, a plasma protein, has been reported to control thrombin activity by directly ... system is involved in the anti-inflammatory action of antithrombin. This cellular effect of ...

Direct inhibition of thrombin may offer similar anticoagulant properties but also impact the underlying disease process. As we continue to gain experience and develop new DTIs, a new balance may ...

Summary: Ximelagatran is the first orally active direct thrombin inhibitor to be tested in Phase III clinical trials. After oral administration, ximelagatran is rapidly converted to its active ...