However, cell fate specification and tissue patterning involve the interplay of biochemical and mechanical feedback. Therefore, to test for associations between them, new methods were needed.

The tissue in the softer matrix regions started to bulge out and ... This allowed us to generate highly stereotyped patterns of defined shape that have the precise surface geometry of the real crypts ...

Multi-gradient assembloids employ biochemical gradients to mimic developmental pathways, offering a controlled environment to study morphogen-driven tissue patterning while shedding light on ...

Now, in a study titled "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate ...

The exact role of a tissue in an organism depends on what types of cells it contains. For example, the endothelial tissue that lines the human gastrointestinal tract consists of several cell types.

Using an advanced approach called graph contrastive learning, STAIG identifies key spatial features, enabling it to map distinct gene expression patterns to specific tissue regions. "STAIG ...