Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in ...

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at ...

The novel DNA topoisomerase I inhibitor T01 and the microtubule inhibitor MMAE, are conjugated to glycan on Fc via cleavable linkers, thereby achieving synergistic antitumor effects through the ...