ABL Bio’s first-in-class bispecific antibodies for Parkinson’s disease combine unprecedented blood ... through the brain endothelium. Three such RMT systems— transferrin receptor (TfR ...

The blood–brain barrier (BBB ... enter the brain tissue from the blood by a receptor-mediated process. An example of this is the transport of transferrin (Tf) across the BBB.

Getting drugs from the bloodstream into the brain is notoriously difficult because of the presence of the blood–brain ... technology relies on a transferrin receptor-targeting antibody to ...

The blood-brain barrier (BBB) is a cellular fortress that regulates what ... Using rational design, knowledge of a specific receptor on the BBB allows scientists to edit the capsid accordingly, but ...

Each cell is separated from its environment by a barrier called ... And this is because transferrin needs the previously mentioned “ticket”, which is a unique receptor for input, the number ...

According to him, the target for technology transfer is the ‘Grabody-B’ platform, which penetrates the blood-brain barrier ... “most antibodies utilizing the BBB shuttle use the transferrin receptor ...