Medscape6d
Genetic Characterization to Improve Interpretation and Clinical Management of Hepatotoxicity Caused by Tyrosine Kinase Inhibitors
Tyrosine kinase inhibitors (TKIs) are used for the targeted ... in clinical trials enables genetic characterization of drug-induced liver injury events, identified putative mechanisms of injury ...
Nature5y
The Hunt For Kinase Inhibitors
Few, if any, classes of enzymes play a greater role in cell signaling than kinases. The human genome encodes for 518 different kinases, which add phosphate groups to substrates. Researchers ...
The American Journal of Managed Care6d
Discontinuing Versus Switching BTK Inhibitors for Toxicity
Panelists discuss how data from Mansour and colleagues suggesting potential Bruton tyrosine kinase (BTK) inhibitor ...
Too Old to Operate11d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
GlobalData on MSN5mon
Boehringer Ingelheim reports positive results from trial of HER2 lung cancer drug
Zongertinib is an oral HER2 tyrosine kinase inhibitor designed to minimise toxicity ... The trial met its primary endpoint, ...
BioWorld15d
Sichuan Kelun-Biotech Biopharmaceutical discloses new PKMYT1 inhibitors for cancer
Work at Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. has led to the identification of heteroaromatic ring compounds acting as membrane-associated tyrosine-and threonine-specific Cdc2-inhibitory ...