Scientists peel away the mystery of JAK enzymes, which play roles in everything from eczema to ulcerative colitis
Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...
Nature11d
The anaplastic lymphoma kinase in the pathogenesis of cancer
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...
The Harvard Crimson1d
HMS Research Identifies Metabolic Enzyme that Facilitates Lung Cancer Growth
Researchers at the Harvard Medical School discovered that the enzyme GUK1 promotes lung cancer growth by boosting the ...
Nature17y
HTRF® KinEASE™ TK: a new solution for tyrosine kinase screening
1). The phosphorylation of the biotin-tagged generic peptide is initiated by the addition of ATP in the presence of the tyrosine kinase (step 1) and stopped by the addition of a mix containing the ...
Lequotidiendumedecin.fr8d
Une nouvelle arme dans la thrombopénie immunitaire
Résultats positifs pour le rilzabrutinib dans le traitement de la thrombocytopénie immune persistante ou chronique chez l’adulte (Abs. 2552). Dans l’étude pivot de phase 3 Luna 3, qui avait inclus 202 ...
Too Old to Operate11d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
Le BR111 de BioRay, un ADC ciblant des épitopes doubles de ROR1, reçoit l'autorisation formelle d'essai clinique de la part de la NMPA
Le 19 décembre 2024, BioRay Pharmaceutical Co., Ltd. (« BioRay ») a annoncé que l'Administration nationale des produits médicaux (NMPA) avait accepté la demande d'essai clinique pour le produit biolog ...