Under stress, mitochondria rapidly increase their copy number—that is, the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein response, or ...

The UPR has several "branches" that regulate ... indicating that this is a mechanism to adapt mitochondrial function during ER stress. The next question for the team was whether this shutdown ...

The activation of UPR mt not only depends on the TGF-β ... elegans with neuronal mitochondrial stress and observed an extended lifespan, enhanced pathogen resistance, and reduced lipid accumulation.

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proceedings of the National Academy of Sciences , 2015; DOI ...

The mitochondrial unfolded protein response (UPR mt) serves as an important retrograde regulatory pathway that communicates from mitochondria to the nucleus. Various factors, including imbalances ...

In biology classes from high school through university, I learned that mitochondria are little objects that reside within ...

Two years ago, Jae's team explored the question as to how mitochondrial stress is actually reported to the cell. The researchers found a new signaling pathway consisting of the proteins OMA1 ...

They turn the food we eat into the energy our cells can use. But when stress hijacks the process they use to maintain their ...

"When we see these mitochondrial changes, is that a sign that a tissue is under stress? We're exploring that idea as well." ...

Mitochondria, the tiny structures inside our cells that generate energy, may also play a previously unrecognized role in mind-body interactions. Based on new studies of stress responses, this insight ...