Patients do not typically transition to an upper motor neuron bladder or bowels Bladder and bowel anal-rectal sphincter remains flaccid, becomes highly complaint and is characterized by underactivity ...

Motor neurone disease (MND ... ALS affects both the upper motor neurones that travel from the brain to the spinal cord and the lower motor neurones, which branch out to the various muscle groups ...

This abnormal reflex is typically a sign of an upper motor neuron lesion ... the brain and other areas of the body, as well as a lower trigger threshold for stretch reflexes.