If proteins like VEGF are simply injected into blood, they are rapidly cleared, says Swingle. This can be overcome by delivering the recipes for making proteins instead, in the form of mRNA ...

The capability of the VSMCs to react to hypoxic stimuli was assessed by intracellular calcium and ATP measurements and by VEGF mRNA expression analysis. VSMCs respond to hypoxia with decreases in ...

Results: Vegfa mRNA expression in retina and choroid significantly ... Hif-1α did not change significantly with hypoxia or re-oxygenation. Vegf protein did not increase in retina or choroid ...

These mRNA-based therapies were produced with ... a bispecific molecule that targets PD-L1 and VEGF. In-licensed from Biotheus in October 2023, this asset has generated compelling Phase II data ...

In September 15 Journal of Clinical Investigation, Hairong Peng and colleagues at the University of Pittsburgh, Pennsylvania, US, show that simultaneous expression of bone morphogenetic protein-4 (BMP ...

Reports Q4 revenue EUR 1.19B vs. EUR 1.48B last year. “From the very beginning, BioNTech’s (BNTX) vision has been to translate our science into ...

Our mRNA cancer immunotherapy FixVac and iNeST and our bispecific anti-PD-L1/anti-VEGF antibody BNT327. We believe that these programs have disruptive potential and aligned with our vision.