44 There is now clearly more to learn. In this evolutionary context, how did a gene function like p53 arise and what does (did) it do for the animal? Worms and flies are born with a body plan that ...

The p53 gene is one of the most important in the ... The paradigm shift is that, instead of asking 'What does p53 do' we were able to use a lesser-functioning but cancer-predisposing genetic ...

The researchers were surprised by the finding because PIPK1-alpha mostly exists in cell membranes, but mutant p53 does most of ... copies of the p53 gene than humans do, and found that it ...

The p53 tumour-suppressor gene integrates ... Why does p53 regulate the expression of so many genes — are most of them 'artefacts', which coincidentally have p53-binding sites, but do not ...

A study to look at why long-lived bats do not get cancer has broken new ground about the biological defenses that resist the ...

TP53 is a gene located on chromosome 17 that, when normal, stops cells from growing and dividing. You can inherit a TP53 mutation from your parents or develop one later in life. An inherited TP53 ...

If a cell loses the p53 gene when DNA becomes mutated, the cell proliferates in an uncontrolled way and does not self-destruct. However, certain cancers, such as kidney cancer, have few p53 mutations.

When they lose function, cancer is left to grow. The most important tumor suppressor is the protein p53. The gene coding p53 is mutated in about 40 percent of all cancers, and the remaining ...

They found larger species do tend to have a slightly higher prevalence ... Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also ...

Researchers have known for some time that the tumor-suppressor gene p53 plays a vital role ... But under normal conditions, the cell does not need p53. In fact, the presence of p53 proteins ...

The human gene responsible for triggering tanning in response to sunlight has been found – it is a well-known tumour-suppressor called p53. Tanning is activated by ultraviolet light and involves ...