RNA plays an important role in this inactivation process. Specifically, Xist RNA, a long noncoding RNA molecule, is responsible for crumpling up one copy of an X chromosome in each female cell.

This led him to hypothesize that the XIST RNA-protein complex might underlie the autoimmunity female bias since XIST isn’t expressed in males. To test his theory, Chang and his team genetically ...

Inactivation of the X chromosome requires the Xist gene, whose product, a noncoding RNA, associates with chromatin on the inactive X chromosome and causes transcriptional silencing. In an Advanced ...

hybridized with the 14A XIST cDNA probe. The probe hybridizes only to RNA samples from cell lines which contain an inactive X chromosome.

Targeting vimentin and/or the long noncoding RNA (lncRNA) ‘XIST’ could be an effective therapeutic strategy for treating aggressive breast cancer. Vimentin is a type III intermediate filament ...

Targeting vimentin and/or the long noncoding RNA (lncRNA) 'XIST' could be an effective therapeutic strategy for treating aggressive breast cancer. Vimentin is a type III intermediate filament (IF ...