RNA plays an important role in this inactivation process. Specifically, Xist RNA, a long noncoding RNA molecule, is responsible for crumpling up one copy of an X chromosome in each female cell.
This led him to hypothesize that the XIST RNA-protein complex might underlie the autoimmunity female bias since XIST isn’t expressed in males. To test his theory, Chang and his team genetically ...
Inactivation of the X chromosome requires the Xist gene, whose product, a noncoding RNA, associates with chromatin on the inactive X chromosome and causes transcriptional silencing. In an Advanced ...
hybridized with the 14A XIST cDNA probe. The probe hybridizes only to RNA samples from cell lines which contain an inactive X chromosome.
Targeting vimentin and/or the long noncoding RNA (lncRNA) ‘XIST’ could be an effective therapeutic strategy for treating aggressive breast cancer. Vimentin is a type III intermediate filament ...
The Queen Zone on MSN11mon
Why Autoimmune Diseases Disproportionately Affect WomenHowever, the research revealed that this process also generates complex molecular structures called Xist complexes (long ...
Targeting vimentin and/or the long noncoding RNA (lncRNA) 'XIST' could be an effective therapeutic strategy for treating aggressive breast cancer. Vimentin is a type III intermediate filament (IF ...
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