The G1–S transcriptional programme is robustly activated by positive feedback mechanisms, creating an 'all-or-none' switch that leads to cell cycle commitment. Inactivation of G1–S ...

In essence, cell cycle arrest at these critical checkpoints represents a survival mechanism ... are separated by gaps of varying length called G1 and G2 (Fig 1 Fig 1. The cell cycle and the response ...

The stages of this cycle include: Gap 1 (G1) phase, DNA synthesis ... M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint. They aid the formation ...

Such regulatory mechanisms are known as cell cycle checkpoints, according to Cooper. There are three checkpoints within the G1, G2 and M phases. Damaged DNA stops cell cycle progression in the G1 ...

which suggests that CDK4 amplifications may represent yet another alternative pathogenetic mechanism of disrupting the G1/S-phase cell cycle regulatory checkpoint in MCL. Given the high frequency of ...

These biochemical pathways have been termed "checkpoints ... In summary, "CDK4/6 is a key mediator of cell cycle progression through the G1 phase, the time when a cell prepares to initiate ...

Replicative stress can be enhanced by targeting critical DNA replication checkpoints and replication ... and Advanced Cell Diagnostics. Bio-Techne has united these brands to provide researchers ...

Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic ...

From this and other discoveries, including the discovery of the RAD9 gene with former postdoc Ted Weinert, Hartwell hypothesized that checkpoints regulate the sequence of events in mitosis.1 His ...

A new method can capture detailed information about all four phases of the cell cycle in real time using fluorescent proteins. Michael Lin was always curious about cell biology, but he became ...