The pathophysiologic effects of trauma and chronic stress on the tripartite glutamatergic synapse are believed to underlie various biological abnormalities observed across many neuropsychiatric ...

SPG302 aims to fill this gap by targeting glutamatergic synapse loss, a key contributor to all symptom domains. 3 Schizophrenia affects approximately 24 million people globally, with a prevalence of ...

Modifications of the intrinsic currents in neuronal circuits are more likely to result in loss of function than changes in synaptic strength.