Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow ...

Here, we focus on one family of adaptors, termed RACKs (receptors for activated C-kinase ... as an example, we will discuss how modulation of binding to adaptor proteins may lead to the design ...

Altogether, the ATM-mediated network is a prime example of a multilayered signalling network brought to action by a single, powerful protein kinase that sparks a rapid, highly structured cascade ...

University of Michigan researchers have identified herpes virus saimiri, which infects the T cells of squirrel monkeys, as a ...

They adjusted the CaMKII protein in young mice to mimic what happens in aging brains. The result? These young mice started ...

Protein kinase inhibitors can be subdivided according ... provides an approach to treating such diseases. One example of a drug being used in this way is the tyrosine kinase inhibitor dasatinib ...

A protein kinase is an enzyme that modifies other proteins -- in this ... “This is one of the first examples of a kinase that has an inhibiting effect on calcium channels in the heart.” Researchers ...

Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the ...

Protein kinase inhibitors are drugs that can inhibit the action of protein kinases. Protein kinases add a phosphate group to a protein to switch it on or off in a process known of as phosphorylation.

A group has found that heart fibrosis is regulated by the enzyme protein kinase N (PKN). As there are no therapies targeting PKN, controlling this enzyme is a promising therapeutic target to ...