Plasma membrane cholesterol accumulation affects α 1-AR signaling and promotes loss of SMC contractile markers in vitro. ABCA1 and ABCG1 (ATP-binding cassette transporter A1 and G1) mediate ...
Scientists discovered that elevated oxysterol traps ABCA1 in lysosomes, disrupting cholesterol metabolism and increasing Alzheimer’s risk. Lowering oxysterol restored ABCA1 function and reduced ...
The researchers focused on ABCA1, a protein that aids in producing high-density lipoprotein (HDL) cholesterol, often referred to as “good” cholesterol. In healthy brains, HDL supports cell ...
Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its ...
Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...
Our understanding of the relationship between the atheroprotective activities of HDL and heterogeneity of HDL particles has advanced greatly. HDL particles are highly heterogeneous in structure ...
Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...
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