Here we show that much of the sustained surround antagonism in certain on-center ganglion cells results from lateral inhibition in the inner retina, via GABAergic amacrine cells, and that the ...

It consists of layers of neurons: light-sensitive photoreceptor cells, bipolar cells, horizontal cells, amacrine cells and retinal ganglion cells, which transmit the visual information to other ...

Vector-borne neurons are morphologically, transcriptomically and physiologically similar to bipolar and amacrine/ganglion-like neurons. These results represent a key step forward in developing a ...

and provide information about the reciprocal synapses between the rod bipolar cells and AII and A17 amacrine cells in the inner retina. 2 ffERG is recorded under dark-adapted and light-adapted ...

A 30% reduction of large amacrine cells, which are believed to play a role in colour vision, was reported upon post-mortem examination of treated rats relative to controls. Levels of glutathione, an ...

The functional properties of a given ganglion cell must necessarily depend on the excitatory and inhibitory inputs it receives from bipolar cells and from amacrine cells. The many different types of ...

Research by Chen et al. (2023b) identified rod BCs, cone BCs, and amacrine cells as retinal neuronal cell types most strongly associated with DR risk. The gene Neurexin 3, a DR risk candidate, is ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

This study demonstrates the critical role of Afadin on the generation and maintenance of complex cellular layers in the mouse retina. The data are solid, which provides important insights into how ...

Identifying biomarkers of Alzheimer’s disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies.

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.