The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...

This protective effect worked through the cGAS-STING-TBK1 immune pathway. The research primarily used postmortem brain tissue and laboratory models, which may not fully reflect the complexity of ...

The herpes simplex virus type can affect the brain in a number of ways including ... “Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease,” and led ...

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found ...

“This led us to explore a specific immune response pathway in the brain, the cGAS-STING pathway,” he detailed. “We found that molecules of this pathway are present where HSV-1 and modified ...

These findings could lead to new treatments targeting infections and the brain’s immune response ... Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease. Cell ...

When brain cells were infected with HSV-1, tau became modified through phosphorylation, which appeared to protect cells from death. This protective effect worked through the cGAS-STING-TBK1 immune ...

Modeling in human brain organoids shows that HSV-1 infection elevates ... This modeling prompts investigation into the cGAS-STING-TBK1 pathway products, nuclear factor (NF)-κB and IRF-3, which ...

Figure 3 Sensing of nucleic acids by RLR-MAVS and cGAS-STING pathway. Retinoic acid-inducible gene-I (RIG ... and induced anti-inflammatory cytokines in the plasma and brain of AD mice through the ...

They examined a molecular pathway in brain cells called cGAS-STING, which is involved in phosphorylation. Unlike beta-amyloid, tau is found inside cells and so is harder to study. Using a technique ...

Other mitophagy pathways ... (cGAS) is a cellular DNA sensor that primarily recognizes double-stranded DNA, i.e., mtDNA, using ATP and GTP as substrates to produce the second messenger cGAMP, which ...