Secondly, they secrete cytokines, including TNF-α and IL-12, which subsequently attract and activate CTLs to the tumor microenvironment (42). In summary, engaging the cGAS-STING pathway within the TME ...

Cytoplasmic mtDNA is also recognized by cGAS and leads to increased expression of cytokines ... the main forms of cell death associated with ALI/ARDS can be concluded into apoptosis, necrosis, and ...

Fat necrosis refers to dead or damaged breast tissue that often manifests as a noncancerous lump under the skin. In most cases, these lumps go away on their own and don’t return. Fat necrosis of ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

This valuable study on Pseudomonas subverting host immunity identifies a new immune evasion strategy. There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastomas (GBM) are treated with high ...

Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People’s Republic of China Department of Chemistry, National University of ...

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.

Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, ...

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