Thick lines represent the preferred pairing for each kinase. (C) According to the classical model of cell cycle control, D-type cyclins and CDK4 or CDK6 regulate events in early G1 phase ...

The cell cycle and its system of checkpoint controls show strong evolutionary conservation. As a result, all eukaryotes — from single-celled yeast to complex multicellular vertebrates — pass ...

Previous studies had found that a few cell cycle proteins, called cyclins, were active during cilia growth, as well as centrioles, which anchor the two sets of chromosomes during cell division. Yet ...

Analysis of cyclins and CDKs in the cell cycle by flow cytometry is more multifaceted than DNA, since different cyclins become active at different parts. For example, cyclins A and B show high ...

The cyclin-dependent kinases (cdks) family and tumor suppressor proteins control these cell cycle checkpoints. Cdks function in tandem with their regulatory subunits, cyclins, in controlling cell ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...