TNF-α is a potent inductor of the inflammatory response, a key cytokine in the development of the innate immune response. Soluble TNF-α acts on many hematopoietic and nonhematopoietic cell types ...

Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...

Here we review evidence for the contribution of cytokines to acute neurodegeneration, focusing primarily on interleukin 1 (IL-1), tumour necrosis factor-α (TNFα) and transforming growth factor ...

6 Isomyosamine is a novel plant alkaloid small molecule shown to regulate the immuno-metabolic system through the modulation of numerous pro-inflammatory cytokines including TNF-alpha (TNF-α), an ...

The traditional understanding of inflammation focused primarily on its acute manifestations, the classic signs of redness, ...

BALTIMORE--(BUSINESS WIRE)--TNF Pharmaceuticals ... through the modulation of numerous pro-inflammatory cytokines including TNF-alpha (TNF-α), an immune cell signaling protein and inflammatory ...

Contrary to established dogma, the spleen is not the principal source of the pro-inflammatory cytokine called tumor necrosis factor (TNF), which drives the sort of system-wide inflammation seen in ...

TNF Pharma begins phase 2b clinical trial to evaluate oral TNF-alpha inhibitor drug candidate isomyosamine: Baltimore Thursday, February 27, 2025, 18:00 Hrs [IST] TNF Pharmaceutic ...

Image Credit: Sino Biological Inc. Disturbance in levels of the key pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and anti-inflammatory cytokines, such as IL-10, IL-4, and TGF-β ...

today announced the initiation of a fully funded Phase 2b clinical trial evaluating oral TNF-alpha (TNF-α) inhibitor drug candidate isomyosamine as a treatment for chronic inflammation associated ...