This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

As a professor of pathology at the University of Michigan, Gabriel Nuñez’s life is dedicated to research on microbes and ...

A study explores how cationic fusogenic liposomes temporarily modify membrane properties during fusion, offering new insights ...

Released mitochondrial DNA (mtDNA) was detected in the cytosol, activating the STING pathway. Triple knockouts, including Stinggt/gt, improved survival and body size, highlighting STING's role in ...

We present an ATC that acts on innate immune cells to promote tumor-cell phagocytosis and facilitate the translocation of tumor-derived antigens from phagolysosomes into the cytosol, where antigen ...

Scientists have uncovered a surprising strategy used by the herpes simplex virus (HSV-1) to reawaken in the body. A new study from the University of Virginia School of Medicine has identified a viral ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

R-708-5p is a stress-regulated microRNA and a potential biomarker for the differential diagnosis of human mood disorders.

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...