This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

A study explores how cationic fusogenic liposomes temporarily modify membrane properties during fusion, offering new insights ...

Scientists have uncovered a surprising strategy used by the herpes simplex virus (HSV-1) to reawaken in the body. A new study from the University of Virginia School of Medicine has identified a viral ...

Released mitochondrial DNA (mtDNA) was detected in the cytosol, activating the STING pathway. Triple knockouts, including Stinggt/gt, improved survival and body size, highlighting STING's role in ...

We investigated whether other members of the MEDLE gene family are similarly exported and selected MEDLE1 (cgd5_4580) and MEDLE6 (cgd6_5490) for epitope tagging. In IFAs, both tagged MEDLE1 and MEDLE6 ...

Autophagosomes are double-membraned vesicles that contain cellular material slated to be degraded by autophagy. An isolation membrane or phagophore forms near autophagic cargo and expands until it ...