Their findings, published in Nature Neuroscience, suggest that different aspects of reward-related behavior are supported by two distinct dopamine receptors, namely D3 and D1. "The previous ...

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...