ALZFORUM29d
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
As opposed to the endosomal recycling pathway, which shuttles proteins between the endosomes and cell surface, the retrograde pathway ferries proteins, including lysosomal enzymes, between the ...
Nature12d
Translocation of classical PKC and cortical granule exocytosis of human oocyte in germinal vesicle and metaphase II stage
After treatment with PKC activator, phorbol 12-myristate 13-acetate (PMA), cPKC translocated to the periphery of oocyte, and cortical granules (CG) exocytosis was found. When the oocytes were ...
eLife29d
Unbiased identification of cell identity in dense mixed neural cultures
This study presents an important application of high-content image-based morphological profiling to quantitatively and systematically characterize induced pluripotent stem cell-derived mixed neural ...
Frontiers12d
Golgi Phosphoprotein 73: The Driver of Epithelial-Mesenchymal Transition in Cancer
Golgi phosphoprotein 73 (GP73, also termed as GOLM1 or GOLPH2) is a glycosylated protein residing on cis-Golgi cisternae and highly expressed in various types of cancer tissues. Since GP73 is a ...
Frontiers12d
A Golgi-Localized Sodium/Hydrogen Exchanger Positively Regulates Salt Tolerance by Maintaining Higher K + /Na + Ratio in Soybean
Soybean cultivar Jidou-7 was obtained from the Institute of Grain and Oil Crops, Hebei Academy of Agricultural and Forestry Sciences, and cultivar Mustang was obtained from Plant Transformation Core ...
eLife18d
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Giamundo et al. present fundamental data with new insights into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling ...