Dermatofibromas, also referred to as fibrous histiocytomas, are common benign growths that present as firm nodules. Lesions are usually less than 1.0 cm ...

Lunit SCOPE® IO now available to SITC members for AI-powered TME profiling, in a collaborative effort to advance cancer immunotherapy ...

First, we present an overview of the histology of the vascular wall and vascular senescence ... predominantly endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and fibroblasts, are ...

S100a4, also termed FSP-1 (fibroblast-specific protein-1), was previously considered ... and one lobe was filled with 4% paraformaldehyde for histology. Paraffin-embedded sections were stained with ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

“It doesn’t surprise me per se, because the theory was always there.” Experiments in the 1960s had revealed that the fibroblast-containing dermal compartment of the skin determines the identity of the ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

Overuse tendinopathy is problematic to manage clinically. People of different ages with tendons under diverse loads present with varying degrees of pain, irritability, and capacity to function.

While it has been believed that RA-FLS are generated in the inflamed synovium through transformation or differentiation of existing synovial fibroblasts, recent interest has expanded towards the role ...

Fibroblast-like synoviocytes (FLS) from rats and patients with RA expressing or not Huntingtin-interacting protein 1 (HIP1) were studied for invasiveness, morphology and cell signalling. HIP1 knockout ...