The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...
An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...
The cGAS-STING pathway begins with an enzyme called cGAS-sensing double-stranded DNA present in the cytosol. It triggers a molecular messenger called cGAMP, which activates a protein called STING.
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