Two new studies represent a big step toward developing innovative molecular therapies capable of disrupting the ...

DelveInsight’s, “HDAC Inhibitor Pipeline Insight” report provides comprehensive insights about 40+ companies and 50+ pipeline ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

2019). Both hippocampal LTP and long-term memory are enhanced by the pharmacological inhibition or genetic ablation of HDAC enzymes, which increase histone acetylation in a CREB-dependent manner ...

Engineered enzymes are poised to have transformative impacts across applications in energy, materials, biotechnology, and medicine. Recently, machine learning has emerged as a useful tool for ...

Histone deacetylase inhibitors (HDACi) are a new class of antineoplastic agents with demonstrable preclinical antitumor activity in both in vitro and in vivo studies in a wide range of ...

Elevated liver enzymes can occur for many reasons. Most often, elevated liver enzymes are temporary and resolve on their own without treatment. Occasionally, elevated liver enzymes require additional ...

bDepartment of Neurological Surgery, Malnati Brain Tumor Institute of the Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA cDepartment ...

Rubisco is the enzyme responsible for carbon fixation in plants, algae and many bacteria. A screen of a comprehensive library of rubisco variants (each with a different single-amino-acid mutation ...

Temperature affects enzyme-catalysed reactions by influencing the rate at which they occur. For a reaction to occur between an enzyme and substrate the two molecules need to collide. At lower ...