The Longevity India Conference 2025 – Rise for Healthy Aging, hosted at the Indian Institute of Science (IISc), concluded its ...

U.S., and colleagues have designed and constructed a lysosome-targeted photoinduced pyroptosis and ferroptosis theranostic nanoplatform M@P by self-assembly of photosensitizer MTCN-3 and ...

Representatives from four leading companies highlight emerging basic and clinical research that drives renewed optimism.

In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s, are progressive conditions marked by neuronal loss, neuroinflammation, and protein ...

So actually, enzyme replacement therapy is only useful if there's a way for the enzyme to get into the cell. So, beyond the lysosome, we can't do that.” Then there’s the promise of cell and gene ...

Mechanistically, Mtb Mce3C can bind host cathepsin B (CTSB), a lysosome-derived non-caspase protease that determines cell modalities. This binding inhibits CTSB's protease activity towards BH3 ...

Obesity is one of the more prevalent diseases, which results in energy imbalance within metabolic tissues and lysosome dysfunction. Less frequent diseases include Niemann-Pick type C (NPC) and Gaucher ...

If you care about Alzheimer’s disease, please read studies about vitamin D deficiency linked to Alzheimer’s and dementia, and ...

In this study, the authors use the zebrafish to investigate how the microbiome affects a specialized gut cell called the lysosome rich enterocyte. They use a combination of functional assays for ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...