Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders.

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, ...

Given that the role of PRMT1 in metabolic regulation has been well-documented, we then investigated whether PRMT1 is involved in transforming 6133 cells through metabolic reprogramming. To assess this ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Our transcriptomic, epigenetic and genomic analyses on 19 immune cell subsets from peripheral blood mononuclear cell of patients with SLE revealed the importance of memory B cells via oxidative ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox ...

Alice A. Greene; Oxidative Phosphorylation in Liver Mitochondria of the Rat Bearing Walker Carcinoma 256 *. Cancer Res 1 February 1960; 20 (2): 233–236. Oxidation was found to be efficiently coupled ...

Ubiquitination is a PTM characterized by the covalent binding of ubiquitin (Ub) molecule to a specific target protein. This essential PTM primarily determines protein stability by marking the target ...