Investigators at the Jacobs School have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain, which could open up new therapeutic targets for treating pain.

A new study shows that enhancing activity of a specific component of 'NMDA' receptors normalizes protein synthesis, neural activity and seizure susceptibility in the hippocampus of fragile X lab mice.

A study of depressed individuals found that an eight‐week treatment with selective serotonin reuptake inhibitors (SSRIs) ...

MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...

A Jacobs School of Medicine and Biomedical Sciences researcher has received National Institutes of Health funding to gain better understanding of the neural mechanisms underpinning drug-mediated ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with ...

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation and is believed to consist of a short-lived phasic and continuous tonic component. Here, we build a ...